Which of the following is a reported pregnancy complication of hepatitis E infection?

• A. PROM
• B. Preterm labor
• C. Gestational diabetes
• D. Hyperemesis

Answer: (A)

Hepatitis E infection during pregnancy, especially in the later stages, can lead to obstetric complications. Among the reported effects, premature rupture of membranes stands out as a documented complication in HEV-infected pregnant women. The infection can provoke placental inflammation and systemic illness that contribute to rupture of the membranes before labor. While other pregnancy issues occur for various reasons, the association between hepatitis E and premature rupture of membranes is the one most consistently reported, making it the best-supported choice.