Which of the following conditions is a known trigger for DIC in pregnancy?

• A. Placental abruption
• B. Gestational diabetes
• C. Hyperemesis gravidarum
• D. Hyperthyroidism

Answer: (A)

DIC in pregnancy is triggered when events cause massive tissue factor release and widespread activation of the coagulation system. Placental abruption releases large amounts of tissue factor into the maternal circulation as the placenta separates, which starts a rapid, consumption-type coagulation process. Platelets and clotting factors get used up, leading to bleeding risks as the body’s clotting system becomes exhausted. The other options don’t typically provoke this kind of systemic coagulation activation—gestational diabetes, hyperemesis gravidarum, and hyperthyroidism involve metabolic or endocrine issues rather than a sudden, large-scale release of tissue factor that drives DIC. In practice, recognizing placental abruption as a DIC trigger guides urgent management to address the underlying cause while providing supportive blood products as needed.