What is the primary treatment for multiple sclerosis relapse during pregnancy?

• A. Corticosteroids
• B. Immunoglobulin therapy
• C. Methotrexate
• D. Biologic agents

Answer: (A)

Relapses during pregnancy are treated primarily with high-dose corticosteroids to rapidly reduce inflammation and shorten the flare. The standard approach is intravenous methylprednisolone, given for about 3 to 5 days, which accelerates recovery without long-term fetal harm when used briefly. Methotrexate is contraindicated in pregnancy due to serious fetal risks, and while immunoglobulin therapies or biologic agents may be considered in specific scenarios, they are not the preferred standard for an acute relapse during pregnancy. Therefore, corticosteroids are the most appropriate first-line treatment.