Prepregnancy serum creatinine values are directly related to risk of adverse events such as IUGR, preterm birth, and preeclampsia.

• A. True
• B. False
• C. Only related to IUGR
• D. Only related to preeclampsia

Answer: (A)

Renal function before conception influences how the body handles the demands of pregnancy. Serum creatinine is a common marker of kidney clearance; higher prepregnancy creatinine suggests reduced glomerular filtration rate and diminished renal reserve. This can contribute to placental dysfunction and hypertensive changes that raise the risk of several adverse outcomes, including fetal growth restriction (IUGR), preterm birth, and preeclampsia. Because renal impairment affects multiple pathways involved in pregnancy, the relationship is not limited to a single complication. So prepregnancy creatinine values are indeed directly related to the risk of these adverse events.