Intrahepatic cholestasis of pregnancy management often includes ursodeoxycholic acid to reduce bile acids.

• A. Ursodeoxycholic acid
• B. Acetaminophen
• C. Insulin
• D. Vitamin C

Answer: (A)

When managing intrahepatic cholestasis of pregnancy, the goal is to reduce toxic bile acids and relieve itching to lower fetal risk. Ursodeoxycholic acid fits this goal because it changes the bile acid pool to be less toxic, improves bile flow in the liver, and decreases the amount of bile acids circulating in the mother's blood and placenta. This helps alleviate pruritus and improves liver function tests, and it’s associated with better fetal outcomes.

Acetaminophen does not affect bile acid levels or cholestasis; it’s mainly for pain or fever. Insulin is used for glucose control in diabetes, not cholestasis. Vitamin C has no established role in treating intrahepatic cholestasis.