In pregnancy, sarcoidosis increases the risk of which complication?

• A. Pre-eclampsia
• B. Hyperemesis gravidarum
• C. Gestational diabetes
• D. Placental abruption

Answer: (A)

Sarcoidosis brings a systemic inflammatory state that can affect vascular function and placental development during pregnancy. This inflammatory milieu can cause endothelial dysfunction and placental insufficiency, both of which are key pathways leading to preeclampsia. Because of these effects, pregnancy in someone with sarcoidosis carries a higher risk of developing preeclampsia compared with those without the condition.

Hyperemesis gravidarum, gestational diabetes, and placental abruption have other typical risk factors and pathophysiologies not directly driven by sarcoidosis, so they are less closely linked to the disease itself.