Congenital toxoplasmosis may present with:

• A. Rash, hepatosplenomegaly, eye inflammation, and developmental delays
• B. Isolated fever only
• C. Isolated jaundice only
• D. No symptoms at birth

Answer: (A)

Congenital toxoplasmosis often involves multiple organ systems and can present with skin, liver/spleen, and eye involvement, along with possible neurodevelopmental delays. The combination of a rash, hepatosplenomegaly, eye inflammation (chorioretinitis), and developmental delays reflects multisystem disease and the CNS/ocular sequelae that can appear in affected newborns. Isolated fever or jaundice alone is not the typical pattern for this infection, and while some infants may be asymptomatic at birth, the presented multisystem involvement is a classic presentation pattern.